Current concepts, advances, and challenges in deciphering the human microbiota with metatranscriptomics

We describe strengths and weaknesses of popular sample preparation, sequencing, and bioinformatics approaches and summarize strategies for their use. We then discuss how human-associated microbial communities have recently been examined and how their characterization may change. We conclude that metatranscriptomics insights into human microbiotas under health and disease have not only expanded our knowledge on human health, but also opened avenues for rational antimicrobial drug use and disease management.PMID:37365103 | DOI:10.1016/j.tig.2023.05.004

Source: Trends in Genetics : TIG - June 26, 2023 Category: Genetics & Stem Cells Authors: Teija Ojala Aino-Elina H äkkinen Esko Kankuri Matti Kankainen Source Type: research