Response to: 'Correspondence on 'Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial by Cai and Peng

We would like to thank Cai and Peng1 for the interest they have expressed in our recently published article ‘Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial’2 and the ARD editorial team to give us the opportunity to address their comments. First, Cai and Peng pinpoint another reason behind the lack of statistical significance of our primary outcome, that is, the shortage of our sample size. As suggested by Cai and Peng we have performed a post-hoc power calculation based on our estimated results (and sample), with p1=0.47 and p2=0.36 (p1 and p2 being the proportion of responders in the active arm and control arms, respectively) and an α risk of 5%, the post-hoc-calculated power is 29.9%. However, we have also performed a post-hoc power calculation based on the sample size that we aimed for (ie,...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: ARD Correspondence response Source Type: research