Menopause and diabetes: a bidirectional association

During the transition to menopause, women undergo metabolic and biochemical changes which increase the risk of T2DM. The major change is an increase in body fat, which occurs mainly in the truncal region, affecting visceral fat as well. Clinically, these changes are apparent as an increase in waist circumference, by a mean of 4.5 cm, according to a recent meta-analysis. Menopause is also associated with a decrease in muscle mass and a significant reduction in energy expenditure, mainly from fat oxidation, which favours an increase in total body weight, without major changes in energy intake.
Source: Maturitas - Category: Primary Care Authors: Tags: Abstract ID: 35 Source Type: research