Emerging evidence for adapting radiotherapy to immunotherapy

Nature Reviews Clinical Oncology, Published online: 06 June 2023; doi:10.1038/s41571-023-00782-xRadiotherapy has several key attributes that make it an attractive combination partner for immunotherapy; however, numerous clinical trials investigating the combination of these two treatment modalities have failed to demonstrate clear improvements in patient outcomes. In this Review, Galluzzi and colleagues discuss the evidence indicating that radiotherapy administered according to standard schedules and target volumes might impair immune fitness and, therefore, propose that adaptation of the radiotherapy regimens to immunotherapy (and not vice versa) might synergistically enhance the antitumour immune response to achieve meaningful clinical benefits.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research