This month in The Journal

The omnigenic hypothesis, which contextualizes the highly polygenic nature of complex traits, proposes that a broad, interconnected gene regulatory network coalesces on a set of core effector genes in relevant tissues. Most heritability, therefore, can be attributed to so-called peripheral pathways comprising the additive trans-effects  of many common variants. In this issue, Iakovliev et al. explore a key component of the omnigenic hypothesis by seeking to identify core (or, per the authors’ terminology, sparse effector) genes for type 1 diabetes.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Editors' Corner Source Type: research