The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in glioblastoma

CONCLUSIONS: Our results provide experimental evidence for repurposing HP as an effective adjunct therapy to inhibit adaptive TMZ resistance in order to enhance the efficacy of chemoradiotherapy in GBM, a strategy that may have broad prospects for clinical application.PMID:37249604 | DOI:10.1158/1078-0432.CCR-22-3971

Source: Clinical Cancer Research - May 30, 2023 Category: Cancer & Oncology Authors: Linyong Shi Hanning Chen Kunxiang Chen Chengzong Zhong Chong Song Yifeng Huang Tong Wang Lei Chen Chiyang Li Annie Huang Hong Li Yuntao Lu Source Type: research