Palladium-catalyzed enantioselective three-component synthesis of α -arylglycine derivatives from glyoxylic acid, sulfonamides and aryltrifluoroborates

Abstract
A palladium-catalyzed enantioselective three-component reaction of glyoxylic acid, sulfonamides and aryltrifluoroborates is described. This process provides modular access to the important α-arylglycine motif in moderate to good yields and enantioselectivies. The formed α-arylglycine products constitute useful building blocks for the synthesis of peptides or arylglycine-containing natural products.

Beilstein J. Org. Chem. 2023, 19, 719–726. doi:10.3762/bjoc.19.52

Source: Beilstein Journal of Organic Chemistry - May 25, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: amino acids asymmetric catalysis multicomponent reaction palladium catalysis Petasis reaction sulfonamides Full Research Paper Source Type: research