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What causes persistent hepatitis B virus (HBV) DNA detection despite tenofovir-containing antiretroviral therapy (ART)? Investigators analysed the occurrence of HBV DNA detection (≥20 IU/mL) among 222 people with HIV/HBV coinfection who started any tenofovir-containing ART, achieved HIV RNA suppression of <200 copies/mL and stayed in follow-up for a median of 8.4 years. After 2 years of ART, 61 (27%) of the 222 people with HIV/HBV had detectable HBV DNA, including 6 (10%) of 61 with HBV DNA of >2000 IU/mL. In multivariable analysis, the odds of HBV DNA detection were reduced with low baseline HBV DNA levels, baseline CD4 counts of >350/µL, hepatitis D virus coinfection (reflecting the inhibitory effect of HDV on HBV) and good adherence. A prior AIDS diagnosis slightly increased the odds; age, sex, ethnicity and prior HBV-active ART had no effect. With ongoing follow-up, HBV DNA detection resolved in 47 (77%) of the 61 subjects. The...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Perspectives Source Type: research