Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells

Differentiation. 2023 Apr 13;131:49-58. doi: 10.1016/j.diff.2023.03.001. Online ahead of print.ABSTRACTThe beating of motile cilia requires the coordinated action of diverse machineries that include not only the axonemal dynein arms, but also the central apparatus, the radial spokes, and the microtubule inner proteins. These machines exhibit complex radial and proximodistal patterns in mature axonemes, but little is known about the interplay between them during motile ciliogenesis. Here, we describe and quantify the relative rates of axonemal deployment for these diverse cilia beating machineries during the final stages of differentiation of Xenopus epidermal multiciliated cells.PMID:37120964 | DOI:10.1016/j.diff.2023.03.001

Source: Differentiation - April 30, 2023 Category: Research Authors: Chanjae Lee Yun Ma Fan Tu John B Wallingford Source Type: research