Recruitment of epitope-specific T  cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection

High-avidity CD8+ T  cells provide protective immunity. However, their recruitment into immune responses alongside lower avidity T cells is not well understood. Straub et al. here show that rare high-avidity clones are selectively expanded from naive precursor repertoires with heterogeneous functionalities. Such pol yclonal recruitment enables flexible immune responses against heterologous re-infection.

Source: Immunity - May 9, 2023 Category: Allergy & Immunology Authors: Adrian Straub, Simon Grassmann, Sebastian Jarosch, Lena Richter, Philipp Hilgendorf, Monika Hammel, Karolin I. Wagner, Veit R. Buchholz, Kilian Schober, Dirk H. Busch Tags: Article Source Type: research