cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T  cell function and anti-tumor immunity

Classically, B7 ligands on antigen-presenting cells (APCs) activate the T  cell co-stimulatory receptor, CD28. Zhao et al. reveal that B7 on T cells can activate CD28 in cis at endocytosis-associated membrane curvatures. This cis-signaling promotes anti-tumor T cell responses and explains how T cells sustain functionality in APC-sparse tissues.

Source: Immunity - May 8, 2023 Category: Allergy & Immunology Authors: Yunlong Zhao, Christine Caron, Ya-Yuan Chan, Calvin K. Lee, Xiaozheng Xu, Jibin Zhang, Takeya Masubuchi, Chuan Wu, Jack D. Bui, Enfu Hui Tags: Article Source Type: research