M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer ’s patch

Despite the critical importance of immune development in early life, our mechanistic understanding of this process is limited. Torow et  al. demonstrate that postnatal establishment of intestinal microbe-host interaction is not expressly driven by early microbial colonization, but rather the maturation of Peyer’s patch M cells and antigen-presenting cells.

Source: Immunity - May 1, 2023 Category: Allergy & Immunology Authors: Natalia Torow, Ronghui Li, Thomas Charles Adrian Hitch, Clemens Mingels, Shahed Al Bounny, Niels van Best, Eva-Lena Stange, Britta Simons, Tiago Mai é, Lennart Rüttger, Narasimha Murthy Keshava Prasad Gubbi, Darryl Adelaide Abbott, Adam Benabid, Michael Tags: Article Source Type: research