Transition-metal-catalyzed domino reactions of strained bicyclic alkenes

Abstract
This review presents a comprehensive overview of transition-metal-catalyzed domino reactions of strained bicyclic alkenes, including both homo- and heterobicyclic alkenes. These compounds are important synthons in organic synthesis, providing an important platform for the construction of biologically/medicinally significant compounds which bear multiple stereocenters. The review has been divided according to the metal used in the reaction. An overview of the substrate scope, reaction conditions, and their potential applications in organic synthesis is discussed. A comprehensive outlook on the reactivity paradigms of homo- and heterobicyclic alkenes is discussed and should shed light on future directions for further development in this field.

Beilstein J. Org. Chem. 2023, 19, 487–540. doi:10.3762/bjoc.19.38

Source: Beilstein Journal of Organic Chemistry - April 24, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: bicyclic alkenes cascade catalysis domino transition-metal-catalyzed Review Source Type: research