Transition-metal-catalyzed C – H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview

Abstract
The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X = S, Se, O) offered straightforward access to high value-added compounds. This review will highlight the main advances made in the field with the transition-metal-catalyzed functionalization of C(sp2) and C(sp3) centers with SCF3, SeCF3, or OCH2CF3 groups among others, by C–H bond activation. The scope and limitations of these transformations are discussed in this review.

Beilstein J. Org. Chem. 2023, 19, 448–473. doi:10.3762/bjoc.19.35

Source: Beilstein Journal of Organic Chemistry - April 17, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: C – H bond activation emergent fluorinated groups homogeneous catalysis organofluorine chemistry palladium synthetic method Review Source Type: research