Pathology updates and diagnostic approaches to hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a complex, often under-recognized hyperinflammatory immune dysregulation syndrome arising in a diverse range of clinical scenarios and conditions. The accurate and timely diagnosis of HLH is crucial for patient survival, and usually requires a high level of clinical suspicion. The histologic corollary to clinical HLH – hemophagocytosis – is neither necessary or sufficient for the diagnosis of HLH, as it may be seen in a variety of reactive conditions, or may be absent in true HLH.

Source: Diagnostic Histopathology - April 12, 2023 Category: Pathology Authors: Alexander Kikuchi, Kunwar Singh, Eric Gars, Robert S. Ohgami Tags: Mini-symposium: lymphoreticular pathology Source Type: research