Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone

Nature Reviews Rheumatology, Published online: 06 April 2023; doi:10.1038/s41584-023-00935-3Long-term treatment with the anti-resorptive drug denosumab results in a continuous gain in bone mineral density, whereas denosumab withdrawal results in a transient overshoot in bone turnover, with rapid bone loss. This Perspective explores the potential mechanisms underlying these effects.

Source: Nature Reviews Rheumatology - April 6, 2023 Category: Rheumatology Authors: Serge Ferrari Bente Langdahl Source Type: research