Mitochondrial fumarate implicated in inflammation

Nature Reviews Rheumatology, Published online: 06 April 2023; doi:10.1038/s41584-023-00963-zNew findings suggest that inhibition of macrophage fumarate hydratase leads to the release of mitochondrial RNA, which in turn mediates type I interferon production.

Source: Nature Reviews Rheumatology - April 6, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research