Continuous flow synthesis of 6-monoamino-6-monodeoxy- β -cyclodextrin

Abstract
The first continuous flow method was developed for the synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin starting from native β-cyclodextrin through three reaction steps, such as monotosylation, azidation and reduction. All reaction steps were studied separately and optimized under continuous flow conditions. After the optimization, the reaction steps were coupled in a semi-continuous flow system, since a solvent exchange had to be performed after the tosylation. However, the azidation and the reduction steps were compatible to be coupled in one flow system obtaining 6-monoamino-6-monodeoxy-β-cyclodextrin in a high yield. Our flow method developed is safer and faster than the batch approaches.

Beilstein J. Org. Chem. 2023, 19, 294–302. doi:10.3762/bjoc.19.25

Source: Beilstein Journal of Organic Chemistry - March 9, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: azidation continuous flow β -cyclodextrin H-cube 6-monoamino-6-monodeoxy- monosubstitution reduction Full Research Paper Source Type: research