Glucose-6-phosphate dehydrogenase is dispensable for human erythroid cell differentiation in vitro

Hundreds of millions of people worldwide have a deficiency of glucose-6-phosphate dehydrogenase (G6PD), a predominant enzyme in the metabolism of erythrocytes [1]. G6PD is involved in the synthesis of reduced nicotinamide adenine dinucleotide phosphate (NADPH), an antagonist of oxidative stress. Consequently, G6PD-deficient erythrocytes are vulnerable to life-threatening hemolysis in peripheral blood when exposed to oxidation inducers [2]. In the absence of oxidative stress inducers, G6PD-deficient individuals are asymptomatic and live normally, implying normal erythrocyte production.

Source: Experimental Hematology - February 17, 2023 Category: Hematology Authors: Kanyarat Boonpeng, Nutpakal Ketprasit, Attakorn Palasuwan, Kasem Kulkeaw, Duangdao Palasuwan Tags: Article Source Type: research