IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via I κBζ-dependent induction of ELF3

ConclusionAltogether, our results establish ELF3 as an important mediator of the synergistic effect of IL-17A and TNF in synovial fibroblasts. The findings provide novel information of the pathogenic mechanisms of IL-17A in chronic arthritis and implicate ELF3 as a potential therapeutic target.

Source: Rheumatology - July 6, 2022 Category: Rheumatology Source Type: research