Cancer-associated cachexia — understanding the tumour macroenvironment and microenvironment to improve management

Nature Reviews Clinical Oncology, Published online: 20 February 2023; doi:10.1038/s41571-023-00734-5Cachexia is a multi-organ syndrome characterized by substantial weight loss that affects a majority of patients with cancer and contributes to cancer-related mortality. The authors of this Review discuss the contribution of both the tumour macroenvironment and microenvironment to the inflammatory and metabolic processes involved in cancer-associated cachexia and provide an overview of the therapeutic strategies developed to manage this syndrome.

Source: Nature Reviews Clinical Oncology - February 20, 2023 Category: Cancer & Oncology Authors: Josep M. Argil és Francisco J. L ópez-Soriano Britta Stemmler Silvia Busquets Source Type: research