Advancing CAR T cell therapy through the use of multidimensional omics data

Nature Reviews Clinical Oncology, Published online: 31 January 2023; doi:10.1038/s41571-023-00729-2Data obtained using omics technologies can offer important insights into various aspects of chimeric antigen receptor (CAR) T cell therapy. In this Review, the authors provide an overview of the multidimensional profiling technologies that have been applied in investigations of CAR T cell therapy. They then discuss the ways in which multi-omics data obtained through such analyses can be used to elucidate CAR targets, factors associated with response or resistance to therapy, and mechanisms underlying the associated toxicities, which could potentially be exploited to improve the efficacy and safety of CAR T cell therapies.

Source: Nature Reviews Clinical Oncology - January 31, 2023 Category: Cancer & Oncology Authors: Jingwen Yang Yamei Chen Ying Jing Michael R. Green Leng Han Source Type: research