Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T  cells

Alloreactive T  cells cause graft-versus-host disease (GVHD), but how GVHD is maintained once established is unclear. Using T cell clone tracking, parabiosis of GVHD mice and computational modeling, Sacirbegovic et al. demonstrate that progenitor-like T cells within affected tissues maintain GVHD locally, most ly independent of blood-derived T cells.

Source: Immunity - January 30, 2023 Category: Allergy & Immunology Authors: Faruk Sacirbegovic, Matthias G ünther, Alessandro Greco, Daqiang Zhao, Xi Wang, Meng Zhou, Sarah Rosenberger, Martin H. Oberbarnscheidt, Werner Held, Jennifer McNiff, Dhanpat Jain, Thomas Höfer, Warren D. Shlomchik Tags: Article Source Type: research