Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense

Bioorg Chem. 2023 Jan 20;132:106381. doi: 10.1016/j.bioorg.2023.106381. Online ahead of print.ABSTRACTTwo enantiomeric pairs of macrocyclic acylphloroglucinols (1a/1b and 2a/2b) with an unprecedented carbon skeleton featuring a bicyclo[12.3.1]octadecane core, together with an undescribed biogenetically related long-chain acylphloroglucinol (3), were isolated from Syzygium szemaoense. Their structures were fully established by spectroscopic method, X-ray crystallographic analysis, and ECD calculation. Compounds 1b and 2a/2b exhibited inhibition against death-associated protein kinase-related apoptosis inducing protein kinase 2 (DRAK2) and ATP citrate lyase (ACLY), respectively.PMID:36706532 | DOI:10.1016/j.bioorg.2023.106381

Source: Bioorganic Chemistry - January 27, 2023 Category: Chemistry Authors: Jin-Chang Huang Hong-Hong Xu Qing Shi Chun Lei Jing-Ya Li Ai-Jun Hou Source Type: research