The emerging roles of γδ T cells in cancer immunotherapy

Nature Reviews Clinical Oncology, Published online: 09 January 2023; doi:10.1038/s41571-022-00722-1γδ T cells are lymphocytes with properties of both typical αβ T cell and natural killer cells, notable tissue tropisms, and MHC-independent antitumour functions that make them attractive agents for cancer immunotherapy. In this Review, the authors provide an overview of human γδ T cell subsets, discuss the antitumour and pro-tumour activities of these cells and their prognostic value in patients with cancer, and describe the current landscape of γδ T cell-based immunotherapies.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research