Ultraviolet Light, Unfolded Protein Response, and Autophagy

AbstractThe endoplasmic reticulum (ER) plays an important role in the regulation of protein synthesis. Alterations in the folding capacity of the ER induce stress, which activates three ER sensors that mediate the unfolded protein response (UPR). Components of the pathways regulated by these sensors have been shown to regulate autophagy. The last corresponds to a mechanism of self-eating and recycling important for proper cell maintenance. Ultraviolet radiation (UV) is an external damaging stimulus that is known for inducing oxidative stress, and DNA, lipid, and protein damage. Many controversies exist regarding the role of UV-inducing ER stress or autophagy. However, a connection between the three of them hasn ’t been addressed. In this review, we will discuss the contradictory theories regarding the relationships between UV radiation with the induction of ER stress and autophagy, as well as hypothetic connections between UV, ER stress, and autophagy.

Source: Photochemistry and Photobiology - January 3, 2023 Category: Science Authors: Ver ónica A. Bahamondes Lorca, Shiyong Wu Tags: Special Issue Invited Review Source Type: research