Small intestine and colon tissue-resident memory CD8+ T  cells exhibit molecular heterogeneity and differential dependence on Eomes

The tissue- and context-specific regulation of tissue-resident memory T (TRM) cells, which provide protection in organs and at barrier sites, is an emerging concept. Lin et  al. show that CD8+ TRM cells from the SI vs. the colon exhibit unique molecular and functional attributes along with distinct transcriptional requirements for their maintenance.

Source: Immunity - December 28, 2022 Category: Allergy & Immunology Authors: Yun Hsuan Lin, Han G. Duong, Abigail E. Limary, Eleanor S. Kim, Paul Hsu, Shefali A. Patel, William H. Wong, Cynthia S. Indralingam, Yi Chia Liu, Priscilla Yao, Natalie R. Chiang, Sara A. Vandenburgh, Taylor R. Anderson, Jocelyn G. Olvera, Amir Ferry, Ken Tags: Resource Source Type: research