Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications

Nature Protocols, Published online: 16 December 2022; doi:10.1038/s41596-022-00771-xLiP-MS is an approach based on limited proteolysis that can be used to probe structural changes in proteins. This update highlights recent changes to the method to improve throughput, proteome coverage and data analysis.

Source: Nature Protocols - December 16, 2022 Category: Biomedical Science Authors: Liliana Malinovska Valentina Cappelletti Devon Kohler Ilaria Piazza Tsung-Heng Tsai Monika Pepelnjak Patrick Stalder Christian D örig Fabian Sesterhenn Franziska Els ässer Lucie Kralickova Nigel Beaton Lukas Reiter Natalie de Souza Olga Vitek Paola Pico Source Type: research