B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

The cellular mechanisms controlling mucosal healing (MH) following injury are largely unknown. Using unbiased multi-parameter analysis, Frede and colleagues identified that B cells accumulate in the colonic damaged areas during MH. Surprisingly, B cells played detrimental roles during MH, as their presence hindered the interaction between epithelium and stroma.

Source: Immunity - December 2, 2022 Category: Allergy & Immunology Authors: Annika Frede, Paulo Czarnewski, Gustavo Monasterio, Kumar P. Tripathi, David A. Bejarano, Ricardo O. Ramirez Flores, Chiara Sorini, Ludvig Larsson, Xinxin Luo, Laura Geerlings, Claudio Novella-Rausell, Chiara Zagami, Raoul Kuiper, Rodrigo A. Morales, Fran Tags: Article Source Type: research