Estimating the genome-wide mutation rate from thousands of unrelated individuals

Genotype errors make it difficult to accurately estimate mutation rates in humans from parent-offspring data. We use identity by descent in whole-genome sequence data from population samples to accurately detect germline mutations that have occurred in the past 100 generations and hence estimate the genome-wide mutation rate.

Source: The American Journal of Human Genetics - November 11, 2022 Category: Genetics & Stem Cells Authors: Xiaowen Tian, Ruoyi Cai, Sharon R. Browning Tags: Article Source Type: research