One-pot double annulations to confer diastereoselective spirooxindolepyrrolothiazoles

Abstract
A novel four-component reaction in one pot as an atom- and step-economic process was developed to synthesize diastereoselectively spirooxindolepyrrolothiazoles through sequential N,S-acetalation of aldehydes with cysteine and decarboxylative [3 + 2] cycloaddition with olefinic oxindoles. High synthetic efficiency, operational simplification and reaction process economy using EtOH as solvent, and only releasing CO2 and H2O as side products confer this approach favorable in green chemistry metrics analysis.

Beilstein J. Org. Chem. 2022, 18, 1607–1616. doi:10.3762/bjoc.18.171

Source: Beilstein Journal of Organic Chemistry - November 28, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: azomethine ylides cascade double annulations N,S-acetalation pyrrolothiazoles spirooxindole Full Research Paper Source Type: research