Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane)

Abstract
A series of aryl fluoroalkenyl ethers that contain chlorine and bromine as well as fluorine atoms were prepared in moderate to good yields via the reactions of phenols and 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane) in the presence of KOH. This simple reaction enabled the construction of highly halogenated compounds with the potential for further functionalization. The reaction involved a highly reactive difluoroethylene intermediate, which was produced by the reaction between halothane and KOH.

Beilstein J. Org. Chem. 2022, 18, 1567–1574. doi:10.3762/bjoc.18.167

Source: Beilstein Journal of Organic Chemistry - November 21, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: aryl 1-monofluorovinyl ether electrophilic 1,1-difluoroethene halothane multi-halogenated alkene phenol Full Research Paper Source Type: research