Clinicopathological and immunohistochemical features of solitary fibrous tumor: a case report

AbstractSolitary fibrous tumor (SFT) is an uncommon soft tissue lesion, and even rarer in the oral cavity, where it presents a similar clinical presentation to other lesions that affect the oral cavity. Due to its broad morphological spectrum, the histopathological diagnosis might be challenging and, for a definite diagnosis, the use of complementary tools is usually required, such as immunohistochemistry. We aimed to report a case of a 31-year-old man with an asymptomatic, slightly purplish nodule located on the dorsum of the tongue. The intraoral physical examination revealed the presence of a nodular exophytic lesion and fibrous consistency, measuring 0.9 cm. The histopathological examination revealed a proliferation of mesenchymal cells with variable morphology in a stroma consisting of dense fibrous connective tissue with areas of hyalinization, in addition to numerous vascular structures with a “staghorn-shaped” appearance. Considering the unspecific histopathological features, we performed the immunohistochemistry technique, which revealed diffuse positivity for CD34, focal positivity for Bcl-2, and negativity for S100. Therefore, combined clinical, morphological, and immunohistochemi cal features enable the conclusive diagnosis of solitary fibrous tumor. We emphasize the importance of knowledge about the differential diagnosis of undifferentiated lesions that affect the soft tissues to distinguish SFT from other neoplasms and, thus, perform the most appropriate tr...

Source: Oral Surgery - November 21, 2022 Category: ENT & OMF Authors: Julliany Taverny Sousa, Rani Iani Costa Gon çalo, Leonardo Magalhães Carlan, Janaina Lessa de Moraes dos Santos, Lélia Maria Guedes Queiroz Tags: CASE REPORT Source Type: research