A facile approach to spiro[dihydrofuran-2,3 ' -oxindoles] via formal [4 + 1] annulation reaction of fused 1H-pyrrole-2,3-diones with diazooxindoles

Abstract
There has been developed an easy synthetic approach to spiro[dihydrofuran-2,3'-oxindoles] via a highly diastereoselective formal [4 + 1] cycloaddition reaction of [e]-fused 1H-pyrrole-2,3-diones with diazooxindoles. The described novel heterocyclic systems are heteroanalogues of antimicrobial and antibiofilm fungal metabolites. The developed reaction represents the first example of involving 1H-pyrrole-2,3-diones fused at the [e]-side in a [4 + 1] annulation reaction.

Beilstein J. Org. Chem. 2022, 18, 1532–1538. doi:10.3762/bjoc.18.162

Source: Beilstein Journal of Organic Chemistry - November 10, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: [4 1] annulation catalyst-free diazooxindole 1H-pyrrole-2,3-diones spirooxindole Full Research Paper Source Type: research