An alternative C – P cross-coupling route for the synthesis of novel V-shaped aryldiphosphonic acids

We report an alternative method that requires no solvent and involves a different order of addition of reactants to perform the transition-metal-catalyzed C–P cross-coupling reaction, often referred to as the Tavs reaction, employing NiCl2 as a pre-catalyst in the phosphonylation of aryl bromide substrates using triisopropyl phosphite. This new method was employed in the synthesis of three novel aryl diphosphonate esters which were subsequently transformed to phosphonic acids through silylation and hydrolysis.

Beilstein J. Org. Chem. 2022, 18, 1518–1523. doi:10.3762/bjoc.18.160

Source: Beilstein Journal of Organic Chemistry - November 7, 2022 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: arylphosphonic acids cross-coupling reaction phosphonate esters transition-metal catalysis Letter Source Type: research