Evaluation of Bivalirudin Dosing in Pediatric Extracorporeal Membrane Oxygenation with Renal Insufficiency or Renal Replacement Therapy

Bivalirudin offers several important advantages of relevance to the management of extracorporeal membrane oxygenation (ECMO) patients. This multicenter retrospective analysis evaluated the bivalirudin dosing in pediatric ECMO and correlated these doses with the severity of renal dysfunction. A total of 75 patients were included in this analyses: estimated glomerular filtration rate (eGFR)> 60 ml/min/1.73 m2 (n = 29), eGFR 30–60 (n = 18), eGFR 60 was significantly higher than the dose required in those with renal impairment (0.25 mg/kg/hr in patients with eGFR> 60 and 0.19 mg/kg/hr in patients on RRT, 0.18 mg/kg/hr in patients with eGFR 30–60 and 0.13 mg/kg/hr in patients with eGFR
Source: ASAIO Journal - Category: Medical Devices Tags: Pediatric Circulatory Support Source Type: research