Design, synthesis, and evaluation of chiral thiophosphorus acids as organocatalysts

Abstract A series of P-stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. In order to eliminate the need for C2-symmetry in common CPAs, various scaffolds containing C1-symmetrical thiophosphorus acids were chosen. These new compounds were synthesized and evaluated in the asymmetric transfer hydrogenation of 2-phenylquinoline. Although the efficacy of the thiophosphorus acids was disappointing for this reaction, the work should be useful for developing structural design elements. Beilstein J. Org. Chem. 2022, 18, 1471–1478. doi:10.3762/bjoc.18.154
Source: Beilstein Journal of Organic Chemistry - Category: Chemistry Authors: Tags: asymmetric heterocycles organocatalysis phosphorus synthesis Full Research Paper Source Type: research