The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action

Nature Reviews Endocrinology, Published online: 11 October 2022; doi:10.1038/s41574-022-00745-9This Review discusses the ATP-binding cassette (ABC) proteins ABCB1 and ABCC1 and their preferential cellular export of cortisol and corticosterone, respectively. The article also explores the potential to select therapeutic glucocorticoids on the basis of their different tendencies for export to avoid harmful adverse effects.

Source: Nature Reviews Endocrinology - October 11, 2022 Category: Endocrinology Authors: Kerri Devine Elisa Villalobos Catriona J. Kyle Ruth Andrew Rebecca M. Reynolds Roland H. Stimson Mark Nixon Brian R. Walker Source Type: research