Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

ConclusionsMalignant B cells in PCNSL show transcriptional and spatial intratumor heterogeneity. T cell exhaustion is frequent in the PCNSL microenvironment, co-localizes with malignant cells, and highlights the potential of personalized treatments.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research