Senescence and cancer — role and therapeutic opportunities

Nature Reviews Clinical Oncology, Published online: 31 August 2022; doi:10.1038/s41571-022-00668-4The entry of cells into senescence can act as a barrier to tumorigenesis; however, in certain contexts senescent malignant and non-malignant cells can acquire pro-tumorigenic properties. The authors of this Review discuss the cell-intrinsic and cell-extrinsic mechanisms involved in both the antitumorigenic and tumour-promoting roles of senescent cells, and describe the potential of various senolytic and senomorphic therapeutic approaches in oncology.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research