The dual nature of the nucleolus [Perspectives]

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as "being a multilayered condensate," and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

Source: Genes and Development - September 1, 2022 Category: Genetics & Stem Cells Authors: Tartakoff, A., DiMario, P., Hurt, E., McStay, B., Panse, V. G., Tollervey, D. Tags: Translation, Chromosome Dynamics and Nuclear Architecture, Post-transcriptional Control Perspectives Source Type: research