Renal NF- κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting

How host immune responses contribute to tumor-associated wasting or mortality is unknown. Chen et  al. show that Drosophila yki3SA-gut tumors suppress PGRP-SC2 production to cause gut bacterial overload and systemic IMD-NF-κB activation, promoting host death without affecting wasting. They demonstrate that renal IMD-NF-κB-mediated uric acid accumulation increases host mortality.

Source: Immunity - August 26, 2022 Category: Allergy & Immunology Authors: Yuchen Chen, Wenhao Xu, Yuan Chen, Anxuan Han, Jiantao Song, Xiaoya Zhou, Wei Song Tags: Article Source Type: research