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Interferon-free Regimen for Genotype-4 Chronic Hepatitis CInterferon-free Regimen for Genotype-4 Chronic Hepatitis C

An all-oral, interferon-free regimen consisting of ombitasvir, paritaprevir and ritonavir is effective at treating patients with genotype-4 chronic hepatitis C virus (HCV), according to a new report from AbbVie. Reuters Health Information
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Infectious Diseases News Source Type: news

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In this study, we collected 8 cases of primary cutaneous small cell variant of ALCL and examined their clinical, histologic, and phenotypic features. All patients were middle aged to older adult men; the youngest patient was a 46-year-old man with underlying hepatitis C. In one case, there was a history of lymphomatoid papulosis. In all patients, the disease was in the context of a local regional presentation. Patients were treated with complete excision and/or radiation except in one in whom chemotherapy was administered. In all but one patient, the cutaneous presentation was a regionally confined process; however, in 2 c...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: CME Article Source Type: research
Drug interactions between proton-pump inhibitors and direct-acting antiviral drugs are a great concern in patients with hepatitis C virus infection, because of the potential for suboptimal plasma concentrations of direct-acting antiviral drugs leading to compromised outcomes.1,2 In the phase 3 trial reported by Xavier Forns and colleagues,3 31 (21%) patients with hepatitis C virus infection and compensated cirrhosis receiving glecaprevir plus pibrentasvir were concurrently treated with proton-pump inhibitors.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
Conclusions: Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Publication date: Available online 22 November 2017 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Samah S. Abdel Gawad, Enas Yahia Abu-Sarea, Lamiaa Saleh Schistosomiasis and hepatitis C virus (HCV) are endemic diseases with high prevalence in Africa especially in Egypt. Many sociodemographic and behavioral related determinants were implicated to be associated with schistosomiasis, HCV or coinfection. Recently, polymerase chain reaction (PCR) is used as a diagnostic tool as it is a sensitive and a specific method especially in early stage of infection. But, diagnosis of S. mansoni is dependi...
Source: Beni Suef University Journal of Basic and Applied Sciences - Category: Science Source Type: research
ConclusionsSteatosis and DM may be associated with HCC development in non‐genotype 3 CHC patients with SVR.This article is protected by copyright. All rights reserved.
Source: Liver International - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
ConclusionsWhereas the reduction in serum HCV RNA levels at 1 day after the start of therapy was not associated with treatment outcomes in patients who underwent a 24‐week regimen of IFN‐free therapy, there was an association in patients receiving a 12‐week regimen, and this reduction was predictive of SVR, thus potentially serving as a factor to identify patients at risk of treatment failure.
Source: Journal of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Hepatology Source Type: research
Publication date: November–December 2017 Source:Journal of Pharmacological and Toxicological Methods, Volume 88, Part 2 Author(s): Shawna Abel, Folefac Aminkeng, Kaarina Kowalec, Britt Drogemoller, Galen Wright, Rachel Bader, Jessica Stortz, Eric Yoshida, Sam Lee, Bandar Al-Judaibi, Richard Kim, Edward Tam, Alnoor Ramji, Colin Ross, Bruce Carleton
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
BackgroundWisteria floribunda agglutinin positive Mac‐2 binding protein (WFA+‐M2BP) is a novel serum marker of hepatic fibrosis in adults with chronic hepatitis C. However, it remains unclear whether serum WFA+‐M2BP levels are associated with the progression of liver histology in primary sclerosing cholangitis (PSC) . MethodsTwenty‐eight children and adolescence with pediatric onset‐PSC (M/F = 20/8, median age at diagnosis: 9 years) were enrolled in this study. The relation between serum WFA+‐M2BP levels and clinical characteristics was retrospectively evaluated. Moreover, receiver operating characteristic (ROC...
Source: Hepatology Research - Category: Internal Medicine Authors: Tags: Original Article Source Type: research
The objective of this work was to study the distribution of hepatitis C virus (HCV) genotypes and subtypes from 2010 to 2015 in 1,221 anti-HCV/HCV-RNA-positive specimens from patients living in the metropolitan area of Naples, since HCV genotypes and subtypes remain cornerstones in the management of chronic HCV infection even in the directly acting antivirals era.Methods: The study was carried out on 1,221 anti-HCV/HCV-RNA-positive plasma samples collected between April 2010 and December 2015.Results: Of the 1,221 patients enrolled, 633 (51.9%) were males and 588 (48.1%) were females, with a mean age of 60 ± 13 (SD)...
Source: Intervirology - Category: Virology Source Type: research
CONCLUSIONS: The use of new DAA-based treatments in CHC patients during the first year after the implementation of the SPCHC significantly reduced long-term morbidity and mortality and increased quality of life; demonstrating that this plan is an efficient use of public health resources. PMID: 29152988 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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