The inflammasome pathway: A key player in ocular surface and anterior segment diseases
Inflammasomes are multicomplex molecular regulators with an emerging importance in regulating ocular surface and anterior segment health and disease. Key components found in the eye include NF- κB, NLRP3, NLRC4, NLRP6, ASC, IL-1β, IL-18, and caspase-1. The role of NLRP1, NLRC4, AIM2, and NLRP3 inflammasomes in the pathogenesis of infectious ulcers, DED, uveitis, glaucoma, corneal edema, and other diseases is being studied with many developments. Attenuation of these diseases has been exp lored by blocking various molecules along the inflammasome pathway with agents like NAC, polydatin, calcitriol, glyburide, YVAD, and disulfiram.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Jordan T. Mandell, Juan Pablo de Rivero Vaccari, Alfonso L. Sabater, Anat Galor Tags: Review article Source Type: research