Compression and hypoxia play independent roles while having combinative effects in the osteoclastogenesis induced by periodontal ligament cells.

CONCLUSIONS:   Both compressive force and hypoxia may take part in initiating osteoclastogenesis in orthodontic tooth movement and may have combinatory effects, which could update our concepts of the mechanisms involved in the initiation of bone resorption on the pressure side of the tooth in question.
PMID: 25844508 [PubMed - as supplied by publisher]

Source: The Angle Orthodontist - April 6, 2015 Category: Dentistry Authors: Le Li M, Yi J, Yang Y, Zhang X, Zheng W, Li Y, Zhao Z Tags: Angle Orthod Source Type: research