Targeting strategies of antenatal balanced energy and protein supplementation in Addis Ababa, Ethiopia: study protocol for a randomized effectiveness study
This study will inform global recommendations and operational guidelines for the effective and cost-effective delivery of antenatal BEP supplements. The targeted approaches have the potential for broader scale-up in Ethiopia and other low-resource settings with a high burden of undernutrition among pregnant women.Trial registrationClinicalTrials.gov registration number: NCT06125860. Registered November 9, 2023. (Source: Trials)
Source: Trials - April 30, 2024 Category: Research Source Type: clinical trials
Anterior chamber proliferative membrane interception (AC-PMI)-enhanced trabeculectomy versus trabeculectomy for treating neovascular glaucoma: protocol for a randomized controlled trial
Neovascular glaucoma (NVG) is an irreversible blinding eye disease worldwide and is classified as one of the refractory glaucoma conditions, severely impacting visual function and vision. Unfortunately, effect... (Source: Trials)
Source: Trials - April 29, 2024 Category: General Medicine Authors: Shuqing Zhu, Mengtian Zhou, Haoyu Li, Shaodan Zhang, Shuxia Xu, Haishuang Lin, Yanqie Xie, Rongrong Le and Yuanbo Liang Tags: Study protocol Source Type: research
Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial
Acute kidney injury (AKI) is a significant postoperative complication associated with increased mortality and hospital costs. Hemodynamic strategies, such as goal-directed therapy, might reduce AKI risk. Predi... (Source: Trials)
Source: Trials - April 29, 2024 Category: General Medicine Authors: Javier Ripoll és-Melchor, Laura Carrasco-Sánchez, José L. Tomé-Roca, César Aldecoa, Andres Zorrilla-Vaca, Juan V. Lorente-Olazábal, María J. Colomina, Ana Pérez, Juan I. Jiménez-López, Rosalía Navarro-Pérez, Alfredo Abad-Gurumeta and Manuel I. Tags: Study protocol Source Type: research
Adherence and acceptability of multiple micronutrient supplementation during pregnancy: Study protocol for a cluster-randomized non-inferiority trial in Cambodia
Iron and folic acid (IFA) supplements are currently provided to Cambodian women during pregnancy. However, recent research has found benefits of a multiple micronutrient supplement (MMS) over just IFA alone on... (Source: Trials)
Source: Trials - April 29, 2024 Category: General Medicine Authors: Mai-Anh Hoang, Hou Kroeun, Rolf Klemm, Aman Sen Gupta, Ngik Rem, Sokchea Meng, Sophonneary Prak, Kim Rattana, Mary Chea, Crystal D. Karakochuk, Cassandra Sauer, Ashutosh Mishra, Diwakar Mohan and Meredith Jackson de-Graffenried Tags: Study protocol Source Type: research
Adherence and acceptability of multiple micronutrient supplementation during pregnancy: Study protocol for a cluster-randomized non-inferiority trial in Cambodia
DiscussionFindings from this study will guide an effective and feasible MMS scale-up strategy for Cambodia. Additionally, the findings will be shared globally with other stakeholders planning to scale up MMS in other countries.Trial registrationNCT05867836 (ClinicalTrials.gov, registered May 18, 2023). (Source: Trials)
Source: Trials - April 29, 2024 Category: Research Source Type: clinical trials
Anterior chamber proliferative membrane interception (AC-PMI)-enhanced trabeculectomy versus trabeculectomy for treating neovascular glaucoma: protocol for a randomized controlled trial
This study aims to explore a promising new surgical approach for managing NVG and contribute to the advancement of glaucoma treatment strategies.Trial registrationChiCTR ChiCTR2200055138. Registered on 01 January 2022. https://www.chictr.org.cn/showproj.html?proj=145255. (Source: Trials)
Source: Trials - April 29, 2024 Category: Research Source Type: clinical trials
Miracle friends and miracle money in California: a mixed-methods experiment of social support and guaranteed income for people experiencing homelessness
DiscussionThis randomized controlled trial will determine whether innovative interventions involving volunteer phone support and basic income reduce social isolation and improve housing outcomes for people experiencing homelessness. Although we enrolled unhoused individuals who initially expressed interest in the Miracle Friends program, the study team could not reach approximately 30% of individuals referred to the study. This may reflect the general lack of stability in the lives of people who are unhoused or limitations in the appeal of such a program to some portion of the unhoused population.Trial registrationClinical...
Source: Trials - April 29, 2024 Category: Research Source Type: clinical trials
Hypotension prediction index guided goal-directed therapy to reduce postoperative acute kidney injury during major abdominal surgery: study protocol for a multicenter randomized controlled clinical trial
This study explores the potential of HPI-guided hemodynamic management in reducing AKI after major elective abdominal surgery, with implications for postoperative outcomes and patient care.Trial registrationClinicalTrials.gov NCT05569265. Registered on October 6, 2022. (Source: Trials)
Source: Trials - April 29, 2024 Category: Research Source Type: clinical trials
Assessing fragility of statistically significant findings from randomized controlled trials assessing pharmacological therapies for opioid use disorders: a systematic review
The fragility index is a statistical measure of the robustness or “stability” of a statistically significant result. It has been adapted to assess the robustness of statistically significant outcomes from rand... (Source: Trials)
Source: Trials - April 27, 2024 Category: General Medicine Authors: Leen Naji, Brittany Dennis, Myanca Rodrigues, Monica Bawor, Alannah Hillmer, Caroul Chawar, Eve Deck, Andrew Worster, James Paul, Lehana Thabane and Zainab Samaan Tags: Review Source Type: research
Assessing fragility of statistically significant findings from randomized controlled trials assessing pharmacological therapies for opioid use disorders: a systematic review
ConclusionsOur results suggest that approximately eight participants are needed to overturn the conclusions of the majority of trials in opioid use disorder. Future work should focus on maximizing transparency in reporting of study results, by reporting confidence intervals, fragility indexes, and emphasizing the clinical relevance of findings.Trial registrationPROSPERO CRD42013006507. Registered on November 25, 2013. (Source: Trials)
Source: Trials - April 27, 2024 Category: Research Source Type: clinical trials
Adjustment of positive end-expiratory pressure to body mass index during mechanical ventilation in general anesthesia: BodyVent, a randomized controlled trial
In patients requiring general anesthesia, lung-protective ventilation can prevent postoperative pulmonary complications, which are associated with higher morbidity, mortality, and prolonged hospital stay. Appl... (Source: Trials)
Source: Trials - April 26, 2024 Category: General Medicine Authors: Helene Selpien, Christine Eimer, David Thunecke, Jann Penon, Dirk Sch ädler, Ingmar Lautenschläger, Henning Ohnesorge and Tobias Becher Tags: Study protocol Source Type: research
Gamma oscillations induced by 40-Hz visual-auditory stimulation for the treatment of acute-phase limb motor rehabilitation after stroke: study protocol for a prospective randomized controlled trial
The incidence of hemiparetic limb dysfunction reaches 85% in stroke patients, emerging as a critical factor influencing their daily lives. However, the effectiveness of current rehabilitation treatments is con... (Source: Trials)
Source: Trials - April 26, 2024 Category: General Medicine Authors: Wang Fu, Xiaoming Yu, Minghui Lai, Yuanli Li, Yingting Yang, Yong Qin, Min Yu, Feng Wang and Cong Wang Tags: Study protocol Source Type: research
Effects of different treatment frequencies of electromagnetic stimulation for urinary incontinence in women: study protocol for a randomized controlled trial
Urinary incontinence is highly prevalent in women while pelvic floor muscle training is recommended as the first-line therapy. However, the exact treatment regimen is poorly understood. Also, patients with pel... (Source: Trials)
Source: Trials - April 26, 2024 Category: General Medicine Authors: Chunmei Chen, Jing Zhang, Hong Zhang, Haiyan Li, Jucheng Yu, Yao Pei and Yuan Fang Tags: Study protocol Source Type: research
Effects of different treatment frequencies of electromagnetic stimulation for urinary incontinence in women: study protocol for a randomized controlled trial
DiscussionThe present trial is designed to investigate the effects of a conjunct physiotherapy program for urinary incontinence in women. We hypothesize that this strategy is more effective than pelvic floor muscle training alone, and high-frequency electromagnetic stimulation will be superior to the low-frequency magnetic stimulation group. (Source: Trials)
Source: Trials - April 26, 2024 Category: Research Source Type: clinical trials
Community Health workers United to Reduce Colorectal cancer and cardiovascular disease among people at Higher risk (CHURCH): study protocol for a randomized controlled trial
DiscussionChurch-placed CHWs are trusted influential connectors between communities and health systems. Studies have shown that these CHWs can successfully implement health prevention protocols in churches, including those related to cancer control, making them potentially important community mediators of CRC screening uptake and CRC/CVD risk reduction.Trial registrationNCT05174286; clinicaltrials.gov; August 31st, 2023 (Source: Trials)
Source: Trials - April 26, 2024 Category: Research Source Type: clinical trials
