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The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2
Cell Rep. 2023 Mar 15;42(4):112307. doi: 10.1016/j.celrep.2023.112307. Online ahead of print.ABSTRACTAnimal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Vaccines remain successful at limiting severe disease and death, but the potential for further coronavirus zoonosis motivates the search for pan-coronavirus vaccines. This necessitates a better understanding of the glycan shields of coronaviruses, which can occlude potential antibody epitopes on spike glycoproteins. Here, we compare the structure o...
Source: IAVI Rep - March 27, 2023 Category: Infectious Diseases Authors: Joel D Allen Dylan P Ivory Sophie Ge Song Wan-Ting He Tazio Capozzola Peter Yong Dennis R Burton Raiees Andrabi Max Crispin Source Type: research