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Multi-omics approaches for revealing the complexity of cardiovascular disease
Brief Bioinform. 2021 Mar 17:bbab061. doi: 10.1093/bib/bbab061. Online ahead of print.ABSTRACTThe development and progression of cardiovascular disease (CVD) can mainly be attributed to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces organ damage that will result in end-organ dysfunction characterized by events such as myocardial infarction or stroke. It is also essential to consider other contributory factors to CVD, including cardiac remodelling caused by cardiomyopathies and co-morbidities with other diseases such as chronic kidney disease. Besides, there is a growing amount of evi...
Source: Briefings in Bioinformatics - March 16, 2021 Category: Bioinformatics Authors: Stephen Doran Muhammad Arif Simon Lam Abdulahad Bayraktar Hasan Turkez Mathias Uhlen Jan Boren Adil Mardinoglu Source Type: research

Integrated Machine Learning Approaches for Predicting Ischemic Stroke and Thromboembolism in Atrial Fibrillation.
In this study, we used integrated machine learning and data mining approaches to build 2-year TE prediction models for AF from Chinese Atrial Fibrillation Registry data. We first performed data cleansing and imputation on the raw data to generate available dataset. Then a series of feature construction and selection methods were used to identify predictive risk factors, based on which supervised learning methods were applied to build the prediction models. The experimental results show that our approach can achieve higher prediction performance (AUC: 0.71~0.74) than previous TE prediction models for AF (AUC: 0.66~0.69), an...
Source: AMIA Annual Symposium Proceedings - August 8, 2017 Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research

The hemodynamic effects of the LVAD outflow cannula location on the thrombi distribution in the aorta: a primary numerical study
• Although a growing number of patients undergo LVAD implantation for heart failure treatment, Stroke, caused by the thrombus, is still the most devastating complication for patients who used LVAD. However, the hemodynamic effects of LVAD on the thrombosis distribution in the aorta are still unclear.• This manuscript compared the differences of thrombus distribution in the aorta under two anastomotic position of LVAD outflow cannula in ascending aorta. The numerical study shows that the LVAD outflow cannular location could significantly change the hemodynamic states and the distribution of thrombus in the aorta.
Source: Computer Methods and Programs in Biomedicine - June 6, 2016 Category: Bioinformatics Authors: Yage Zhang, Bin Gao, Chang Yu Source Type: research

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