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Source: Ontario Health Technology Assessment Series

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Total 960 results found since Jan 2013.

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Pre-surgical Nasal Decolonization of < em > Staphylococcus aureus: < /em > A Health Technology Assessment
CONCLUSIONS: Based on the best evidence available, decolonization of S. aureus using nasal mupirocin combined with chlorhexidine body wash prior to cardiothoracic, vascular, orthopaedic, gastrointestinal, or general surgery lowers the incidence of surgical site infection caused by S. aureus in patients who are S. aureus carriers (including methicillin-susceptible and methicillin-resistant strains) (i.e., targeted decolonization). However, nasal mupirocin alone may result in little to no difference in overall surgical site infections and S. aureus-related surgical site infections in pre-surgical patients prior to orthopaedi...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research

Genetic Testing for Familial Hypercholesterolemia: Health Technology Assessment
CONCLUSIONS: Genetic testing for FH has a higher clinical utility than clinical evaluation without a genetic test. It also results in a high diagnostic yield of FH through cascade screening. For individuals with a clinical diagnosis of FH, genetic testing would be a cost-saving and more effective diagnostic strategy. For relatives of index cases confirmed through genetic testing, genetic and lipid cascade screening are both cost-effective compared with no screening, but genetic cascade screening is less cost-effective than lipid cascade screening. We estimated that publicly funding genetic testing for individuals with a cl...
Source: Ontario Health Technology Assessment Series - September 26, 2022 Category: General Medicine Authors: Ontario Health (Quality) Source Type: research