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A novel endonuclease inhibitor exhibits broad-spectrum anti-influenza activity in vitro.
Abstract
Antiviral drugs are important in preventing and controlling influenza, particularly when vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase inhibitors (NAIs), is recommended for treating influenza. The limited therapeutic options and the potential risk of antiviral resistance are driving the search for additional small-molecule inhibitors that act on influenza virus proteins. The acid polymerase (PA) of influenza viruses is a promising target for new antivirals because of its essential role in initiating virus transcription. Here, we characterized a novel compoun...
Source: Antimicrobial Agents and Chemotherapy - July 4, 2016 Category: Microbiology Authors: Jones JC, Marathe BM, Lerner C, Kreis L, Gasser R, Pascua PN, Najera I, Govorkova EA Tags: Antimicrob Agents Chemother Source Type: research
